Crossover trial extraction plan =============================== StatMedAnalysis | Original downloadable worksheet | 6 November 2026 Determine whether a crossover result can contribute a valid paired treatment comparison. How to use this worksheet Record treatment sequences, periods and washout conditions. Identify the reported within-person contrast and whether its uncertainty uses paired observations. Examine potential carryover and period effects using the report and protocol. Avoid treating periods as independent parallel groups. Save a working copy and keep the original blank version. Use public, hypothetical or aggregate information only; do not enter patient identifiers, credentials or confidential records. Keep source evidence in your approved project workspace. Mark unresolved text fields UNKNOWN or NOT REPORTED with a reason; never substitute zero for an unknown count. Project/version __________________ Prepared by role/date __________________ Working fields 1. Sequence allocation and period lengths Response/evidence: _________________________________________________________ ___________________________________________________________________________ 2. Washout and carryover concerns Response/evidence: _________________________________________________________ ___________________________________________________________________________ 3. Outcome timing within periods Response/evidence: _________________________________________________________ ___________________________________________________________________________ 4. Paired analysis population Response/evidence: _________________________________________________________ ___________________________________________________________________________ 5. Within-person contrast and SE Response/evidence: _________________________________________________________ ___________________________________________________________________________ 6. Period or sequence effects addressed Response/evidence: _________________________________________________________ ___________________________________________________________________________ 7. Missing second-period outcomes Response/evidence: _________________________________________________________ ___________________________________________________________________________ 8. Eligible contribution and rationale Response/evidence: _________________________________________________________ ___________________________________________________________________________ Hypothetical worked case A fictional crossover study reports treatment means for each period but no paired variance. A parallel-group SE cannot be assumed to represent the within-person treatment contrast; seek an appropriate paired result or justify another contribution. Decision rule and limitations Include the crossover evidence only with an analysis compatible with the design and review question. State any restriction to first-period data and its rationale instead of silently discarding pairing. Decision _______________________ Remaining uncertainty ____________________ Next action ____________________ Owner / review date ______________________ Independent check and discrepancy resolution _______________________________ Official method or reporting reference checked 6 November 2026 https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-10 This is an original planning aid, not an official checklist, validated instrument, clinical recommendation or certificate of expert approval. Apply the referenced guidance to the specific design and record any additional requirements.