Practical guides · Page 23
Search and filter all practical guidesThe Reviewer Asked: Address Confounding
Build a defensible adjustment rationale by considering the research question, time order, and the roles of candidate variables.
The Reviewer Asked: Explain Your Missing Data
Document missingness, analysis populations, and the assumptions behind your chosen approach before drafting a response.
The Reviewer Asked: Address Multiple Comparisons
Identify the claims and hypothesis family, explain the original analysis plan, and respond transparently without inventing prespecified decisions.
The Reviewer Asked: Justify Your Sample Size
Explain the actual basis for your study size without inventing a prospective calculation after the results are known.
One Decision Changes the Study: Testing Subgroup Differences
Why significant in one subgroup and not another does not establish a subgroup difference, with a worked hypothetical example.
How to Verify a Research Gap Before Starting a Review
A practical evidence-overlap check: compare existing reviews, search dates, protocols and available studies before investing in a new project.
Common Statistical Errors in Medical Manuscripts and How to Avoid Them
Practical checks for p-values, missing data, multiplicity, model assumptions, and causal claims in medical manuscripts.
Survival Analysis in Oncology Research: A Practical Guide
Define oncology time-to-event endpoints, interpret Kaplan-Meier curves and hazard ratios, and handle censoring, competing risks, and nonproportional hazards.
Statistical Analysis Plans for Clinical Trials: Regulatory Considerations
Plan analyses prospectively, define the treatment effect, and document assumptions and changes using ICH and FDA guidance.
Meta-Analysis Best Practices for Medical Research
Plan a reproducible review, choose appropriate synthesis methods, assess bias, and interpret heterogeneity and evidence certainty.